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| | Atorvastatin hemicalcium trihydrate Basic information |
| Product Name: | Atorvastatin hemicalcium trihydrate | | Synonyms: | 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), trihydrate, (βR,δR)-;Atorvastatin hemicalcium trihydrate;Atorvastatin CalciuM Trihydrate (EP);Atorvastatin hemicalcium salt sesquihydrate;Calcium (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate trihydrate;Atorvastatin Calcium (100 mg);Atorvastatin Hemicalcium Sesquihydrate;1H-Pyrrole-1-heptanoicacid, 2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calcium salt, hydrate (2:1:3), (bR,dR)- | | CAS: | 344423-98-9 | | MF: | C66H74CaF2N4O13 | | MW: | 1209.3875664 | | EINECS: | | | Product Categories: | | | Mol File: | 344423-98-9.mol |  |
| | Atorvastatin hemicalcium trihydrate Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | Very slightly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | | form | powder | | color | White to Almost white | | Optical Rotation | [α]/D -9.0 to -5.0°, c =0.5 in DMSO | | Merck | 14,864 | | Major Application | pharmaceutical (small molecule) | | InChIKey | SHZPNDRIDUBNMH-NIJVSVLQSA-L | | CAS DataBase Reference | 344423-98-9 |
| Hazard Codes | T | | Risk Statements | 61-36 | | Safety Statements | 53-26-45 | | WGK Germany | 3 | | HS Code | 2933995300 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Carc. 2
Repr. 1B |
| | Atorvastatin hemicalcium trihydrate Usage And Synthesis |
| Chemical Properties | White or almost white powder. | | Uses | HMG Co-A reductase inhibitor; lipid-regulating drug. | | Definition | ChEBI: A hydrate that is the trihydrate form of atorvastatin calcium. | | Biological Activity | Atorvastatin calcium salt trihydrate is a specific inhibitor of β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase. HMG-CoA reductase is the enzyme th at catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Atorvastatin is used in the treatment of hypercholesterolemia. |
| | Atorvastatin hemicalcium trihydrate Preparation Products And Raw materials |
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