Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-

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Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Suppliers list
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Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Basic information
Product Name:Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-
Synonyms:Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-
CAS:2573035-17-1
MF:C26H45NO6S
MW:499.71
EINECS:
Product Categories:
Mol File:2573035-17-1.mol
Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Structure
Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Chemical Properties
solubility DMSO: Soluble
Ethanol: Soluble
Safety Information
MSDS Information
Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Usage And Synthesis
UsesTauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
References[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. DOI:10.1093/cvr/cvr219
[3] Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. DOI:10.1016/j.ejvs.2016.10.026
[4] BEUERS U. Effects of bile acids on hepatocellular signaling and secretion.[J]. Yale Journal of Biology and Medicine, 1997, 70 4: 341-346.
[5] JEFFREY H BOATRIGHT. Bile acids in treatment of ocular disease.[J]. Journal of ocular biology, diseases, and informatics, 2009, 2 3: 149-159. DOI: 10.1007/s12177-009-9030-x
[6] SHEILA VANG. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases.[J]. Global Advances in Health and Medicine, 2014, 3 3: 58-69. DOI: 10.7453/gahmj.2014.017
Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]- Preparation Products And Raw materials
Tag:Ethane-1,1,2,2-d4-sulfonic acid, 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-(2573035-17-1) Related Product Information
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