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| | Taurodeoxycholic Acid-[d4] Sodium Salt Basic information |
| Product Name: | Taurodeoxycholic Acid-[d4] Sodium Salt | | Synonyms: | Taurodeoxycholic Acid-[d4] Sodium Salt;2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt;Taurine deoxycholic acid-d4 sodium salt;Taurodeoxycholic acid-d4 sodium;Taurodeoxycholic Acid-[d4] Sodium Salt in Methanol;D4-Taurodeoxycholic Acid Sodium Salt;Taurodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%);Taurodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol | | CAS: | 2410279-82-0 | | MF: | C26H46NNaO6S | | MW: | 523.7 | | EINECS: | | | Product Categories: | | | Mol File: | 2410279-82-0.mol | ![Taurodeoxycholic Acid-[d4] Sodium Salt Structure](CAS/20211123/GIF/2410279-82-0.gif) |
| | Taurodeoxycholic Acid-[d4] Sodium Salt Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 3 mg/ml | | form | A crystalline solid | | CAS Number Unlabeled | 1180-95-6 |
| WGK Germany | WGK 2 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | Taurodeoxycholic Acid-[d4] Sodium Salt Usage And Synthesis |
| Description | Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans. | | Uses | Taurodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurodeoxycholic acid[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110 |
| | Taurodeoxycholic Acid-[d4] Sodium Salt Preparation Products And Raw materials |
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