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| | palitantin Basic information |
| Product Name: | palitantin | | Synonyms: | palitantin;(-)-Palitantine;(2R)-2β-(Hydroxymethyl)-3α-[(1E,3E)-1,3-heptadienyl]-5β,6β-dihydroxycyclohexanone;(2R,3S,5R,6R)-rel-3-(1E,3E)-1,3-Heptadienyl-5,6-dihydroxy-2-(hydroxymethyl)-cyclohexanone;Cyclohexanone, 3-(1E,3E)-1,3-heptadien-1-yl-5,6-dihydroxy-2-(hydroxymethyl)-, (2R,3S,5R,6R)-rel- | | CAS: | 15265-28-8 | | MF: | C14H22O4 | | MW: | 254.32 | | EINECS: | | | Product Categories: | | | Mol File: | 15265-28-8.mol |  |
| | palitantin Chemical Properties |
| Melting point | 169℃ (ethyl acetate ) | | alpha | 235461 +4.4° (c = 0.8 in CHCl3) | | Boiling point | 429.064±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.205±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12.219±0.70(predicted) | | form | White solid. | | color | White |
| | palitantin Usage And Synthesis |
| Description | Palitantin is a fungal metabolite originally isolated from P. palitans. It inhibits HIV-1 integrase with IC50 values of 350 and 268 μM for 3’-processing and strand transfer activity, respectively. Palitantin has been used as a standard for dereplication of natural products. | | Uses | Palitantin is an antifungal and antiprotozoal compound. | | IC 50 | Leishmania; Fungal Metabolite | | storage | +4°C | | References | [1] J H BIRKINSHAW H R. Studies in the biochemistry of micro-organisms: Palitantin, C(14)H(22)O(4), a hitherto undescribed metabolic product of Penicillium palitans Westling.[J]. Biochemical Journal, 1936, 30 5: 801-808. DOI: 10.1042/bj0300801
[2] HUIXIAO HONG. Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching[J]. Journal of Medicinal Chemistry, 1997, 40 6: 930-936. DOI: 10.1021/jm960754h
[3] KRISTIAN F. NIELSEN*. Dereplication of Microbial Natural Products by LC-DAD-TOFMS[J]. Journal of Natural Products , 2011, 74 11: 2338-2348. DOI: 10.1021/np200254t |
| | palitantin Preparation Products And Raw materials |
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