Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- manufacturers
- SOS1-IN-7
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- $2140.00
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2026-05-11
- CAS:2755415-30-4
- Purity:
- Supply Ability: 10g
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| | Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- Basic information |
| | Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- Chemical Properties |
| Boiling point | 609.0±65.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | pka | 12.55±0.40(Predicted) |
| | Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- Usage And Synthesis |
| Uses | SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC50s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively[1]. | | IC 50 | SOS1-G12D: 20 nM (IC50); SOS1-G12V: 67 nM (IC50) | | References | [1] Pyridine-pyrimidine derivative, preparation method therefor and pharmaceutical use thereof. WO2021249519A1. |
| | Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- Preparation Products And Raw materials |
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