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| | flobufen Basic information |
| Product Name: | flobufen | | Synonyms: | flobufen;2-Methyl-4-(2',4'-difluoro-4-biphenylyl)-4-oxobutyric acid;4-(2',4'-Difluorobiphenyl-4-yl)-4-oxo-2-methylbutyric acid;VUFB-16066;[1,1'-Biphenyl]-4-butanoic acid, 2',4'-difluoro-α-methyl-γ-oxo-;4-(2',4'-Difluoro-[1,1'-biphenyl]-4-yl)-2-methyl-4-oxobutanoic acid | | CAS: | 112344-52-2 | | MF: | C17H14F2O3 | | MW: | 304.29 | | EINECS: | | | Product Categories: | | | Mol File: | 112344-52-2.mol |  |
| | flobufen Chemical Properties |
| Boiling point | 456.5±40.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | pka | 4.49±0.23(Predicted) | | form | Solid |
| | flobufen Usage And Synthesis |
| Uses | Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis[1][2][3]. | | References | [1] Kvasnicková E, et al. Metabolic pathways of flobufen-a new antirheumatic and antiarthritic drug. Interspecies comparison. Exp Toxicol Pathol. 1999 Jul;51(4-5):352-6. DOI:10.1016/S0940-2993(99)80020-7
[2] Panajotova V, et al. Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. PMID:9205780
[3] Drsata J, et al. Inhibice dekarboxylázy aromatickych aminokyselin protizántlivymi látkami flobufenem a kyselinou 2',4'-difluorbifenyl-4-yloctovou [Inhibition of aromatic amino acid decarboxylases by the anti-inflammatory agent flobufen and 2',4'-difluorbiphenyl-4-acetic acid]. Cesk Farm. 1989 Nov;38(9):407-10. PMID:2635645 |
| | flobufen Preparation Products And Raw materials |
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