4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol

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4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol Basic information
Product Name:4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol
Synonyms:JANEX-1-M
CAS:406484-24-0
MF:C15H13N3O3
MW:283.28
EINECS:
Product Categories:
Mol File:406484-24-0.mol
4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol Structure
4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol Chemical Properties
Boiling point 495.8±40.0 °C(Predicted)
density 1.438±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka7.62±0.40(Predicted)
Safety Information
MSDS Information
4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol Usage And Synthesis
UsesJANEX-1-M is a metabolite of JANEX-1 (HY-15508). JANEX-1 is a JAK3 specific inhibitor, which can effectively inhibit mast cell degranulation and the release of pro-inflammatory mediators[1].
References[1] Uckun FM, et al. CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation. Drug Metab Dispos. 2002 Jan;30(1):74-85. DOI:10.1124/dmd.30.1.74
4-[(4-Hydroxyphenyl)amino]-6-methoxy-7-quinazolinol Preparation Products And Raw materials
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