NSP 805

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:NSP-805
CAS:125068-54-4
Purity:99.10% Package:1mg;48USD|5mg;118USD|10mg;197USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:NSP-805
CAS:125068-54-4
Purity:99.10% Package:1mg;48USD|5mg;118USD|10mg;197USD
Company Name: Aladdin Scientific
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Products Intro: Product Name:NSP-805
CAS:125068-54-4
Purity:99% Package:$240.9/5mg;$408.9/10mg;$720.9/20mg;Bulk package Remarks:99%
Company Name: MedChemexpress LLC  
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Products Intro: Product Name:NSP-805
CAS:125068-54-4
Purity:>98% Package:1000RMB/1mg
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com
Products Intro: Product Name:NSP 805
CAS:125068-54-4
Purity:>=99% Package:1mg Remarks:T24217

NSP 805 manufacturers

  • NSP-805
  • NSP-805 pictures
  • $34.00
  • 2026-05-11
  • CAS:125068-54-4
  • Purity: 99.85%
  • Supply Ability: 10g
  • NSP-805
  • NSP-805 pictures
  • $34.00
  • 2026-04-21
  • CAS:125068-54-4
  • Purity: 99.85%
  • Supply Ability: 10g
NSP 805 Basic information
Product Name:NSP 805
Synonyms:NSP 805;3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-;Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE);5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one;NSP-805, 10 mM in DMSO
CAS:125068-54-4
MF:C17H19N3O2
MW:297.35
EINECS:
Product Categories:
Mol File:125068-54-4.mol
NSP 805 Structure
NSP 805 Chemical Properties
density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka13.84±0.60(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
NSP 805 Usage And Synthesis
UsesNSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.
in vivo

In anesthetized dogs, intravenous (i.v.) injection of NSP-805 produces dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR). The ED50 value for LVdP/dtmax of NSP-805 is 12 μg/kg. When the drugs is administered intraduodenally to anesthetized dogs, the ED50 value for LVdP/dtmax of NSP-805, is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely improves the hemodynamic state of heart failure to normal levels[1]. NSP-805(100 μg/kg) reduces systemic blood pressure significantly, but the increase of chorio-retinal blood flow is less than that at the low dose of NSP-805 (40 μg/kg) in rabbit eyes[2].

References[1] Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. DOI:10.1097/00005344-199306000-00021
[2] Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20. PMID:12420371
NSP 805 Preparation Products And Raw materials
Tag:NSP 805(125068-54-4) Related Product Information
(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone NSP 805 NSP 804