| Company Name: |
Energy Chemical |
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021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Company Name: |
TargetMol |
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400-821-0310 15002144251 |
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xuexiang.shao@tsbiochem.com |
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| | 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile Basic information |
| | 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | powder | | color | white to beige | | InChI | 1S/C13H6Cl2N2O3/c14-11-3-2-10(6-12(11)15)20-13-4-1-9(17(18)19)5-8(13)7-16/h1-6H | | InChIKey | QAYKDRUKUZJJSO-UHFFFAOYSA-N | | SMILES | ClC1=CC=C(OC2=CC=C([N+]([O-])=O)C=C2C#N)C=C1Cl |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Oral |
| | 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile Usage And Synthesis |
| Uses | MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection[1]. | | Biological Activity | MDL-860 is a 5-nitro-2-phenoxybenzonitrile th at exerts broad-spectrum antipicornaviral activity (MIC50 from 0.1-1.5 μg/mL in HeLa cultures) by acting as an irreversible inhibitor against host phosphatidylinositol-4 kinase beta (PI4KB; PtdIns 4-kinase beta; PI4Kbeta; NPIK; PI4K92) via covalent modification of Cys646 located at the bottom of a surface pocket apart from the PI4KB active site. MCL-860 (MIC50 from 0.1-1.5 μg/mL in HeLa cultures). A pleconaril/MDL-860/oxoglaucine consecutive alternating administration (CAA), but not simultaneous daily treatment, is reported to be effective against coxsackievirus B1 infection without the development of drug resistance in newborn mice (75 mg/kg MDL-860 via s.c. every third day on the day following pleconaril and prior to oxoglaucine). | | References | [1] Nikolova I, et al. Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis. Bioorg Chem. 2019 Apr;85:487-497. DOI:10.1016/j.bioorg.2019.02.020 |
| | 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile Preparation Products And Raw materials |
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