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| | vascular endothelial growth factor B Basic information |
| Product Name: | vascular endothelial growth factor B | | Synonyms: | vascular endothelial growth factor B;VEGF-related factor;VEGF-B human;VRF;Human VEGF-B Protein, Fc Tag;VEGFL;VEGFB | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![vascular endothelial growth factor B Structure]() |
| | vascular endothelial growth factor B Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white | | biological source | human |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | vascular endothelial growth factor B Usage And Synthesis |
| Uses | VEGFB (vascular endothelial growth factor B) is one of the seven members of the VEGF family, which also includes VEGF-A, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PIGF (placental growth factor). All these members contain a common VEGF homology domain. This domain forms the core region and contains a cystine knot motif composed of eight invariant cysteine residues. VEGFB, discovered in 1995, is highly expressed in adult myocardium, skeletal muscle, and pancreas. This gene contains seven exons and alternative splicing results in the synthesis of two isoforms VEGF-B167 of 21 kDa and VEGF-B186 of 32 kDa. These isoforms show differential level of expression with VEGF-B167 being the predominantly expressed isoform. VEGFB gene is localized to human chromosome 11q13.
Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains. | | Biological Activity | Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism. |
| | vascular endothelial growth factor B Preparation Products And Raw materials |
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