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| | 1-Butanesulfonyl chloride Basic information |
| | 1-Butanesulfonyl chloride Chemical Properties |
| Melting point | -29°C | | Boiling point | 80-81 °C/9 mmHg (lit.) | | density | 1.208 g/mL at 25 °C (lit.) | | vapor pressure | 0.5 mm Hg ( 20 °C) | | refractive index | n20/D 1.454(lit.) | | Fp | 175 °F | | form | Liquid | | color | Clear colorless to light yellow or light orange | | Water Solubility | DECOMPOSES | | Sensitive | Moisture Sensitive | | BRN | 1748742 | | InChI | 1S/C4H9ClO2S/c1-2-3-4-8(5,6)7/h2-4H2,1H3 | | InChIKey | WEDIIKBPDQQQJU-UHFFFAOYSA-N | | SMILES | CCCCS(Cl)(=O)=O | | CAS DataBase Reference | 2386-60-9(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Butanesulfonyl chloride(2386-60-9) | | EPA Substance Registry System | 1-Butanesulfonyl chloride (2386-60-9) |
| Hazard Codes | C | | Risk Statements | 34-36/37 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | RTECS | EK5950000 | | F | 10-19-21 | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29049090 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B
STOT SE 3 | | Toxicity | mouse,LD50,intraperitoneal,> 100mg/kg (100mg/kg),Nature. Vol. 174, Pg. 737, 1954. |
| | 1-Butanesulfonyl chloride Usage And Synthesis |
| Description | 1-Butanesulfonyl chloride is an antimicrobial agent that inhibits the production of inflammatory substances. It has been shown to inhibit acetylcholinesterase activity and the growth of cancer cells in vitro. 1-Butanesulfonyl chloride is a cross-linking agent that can be used to produce amides, which are used as pharmaceutical preparations for treating inflammatory diseases.
| | Chemical Properties | clear colourless to light yellow liquid | | Uses | 1-Butanesulfonyl chloride has been used in the preparation of:
- ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
- 1-butanesulfonamid-N,N′-1,2-ethanediylbis
- 1-butanesulfonamide-N,N′-1,3-propanediylbis
| | General Description | 1-Butanesulfonyl chloride is a clear, colourless to pale yellow liquid with a pungent odour, primarily used as a chemical intermediate in organic synthesis. It is a highly reactive sulfonyl chloride derivative, commonly employed in the production of sulphonamide drugs, pharmaceutical formulations and active pharmaceutical ingredients (APIs). | | Hazard | 1-Butanesulfonyl chloride is harmful to humans and is corrosive, irritant and acutely toxic. Contact may cause severe skin burns and eye damage. A single exposure may also cause respiratory tract irritation. Inhalation is fatal. | | Purification Methods | It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.] |
| | 1-Butanesulfonyl chloride Preparation Products And Raw materials |
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