Monomethyl auristatin E intermediate-14

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Company Name: Shanghai Haohong Pharmaceutical Co., Ltd.  
Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Monomethyl auristatin E intermediate-14 Basic information
Product Name:Monomethyl auristatin E intermediate-14
Synonyms:Monomethyl auristatin E intermediate-14;D-Alloisoleucine, N-(phenylmethyl)-
CAS:1932791-56-4
MF:C13H19NO2
MW:221.3
EINECS:
Product Categories:
Mol File:1932791-56-4.mol
Monomethyl auristatin E intermediate-14 Structure
Monomethyl auristatin E intermediate-14 Chemical Properties
Boiling point 349.787±25.00 °C(Press: 760.00 Torr)(predicted)
density 1.059±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka2.427±0.24(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Monomethyl auristatin E intermediate-14 Usage And Synthesis
UsesMonomethyl auristatin E intermediate-14 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
References[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931
Monomethyl auristatin E intermediate-14 Preparation Products And Raw materials
Tag:Monomethyl auristatin E intermediate-14(1932791-56-4) Related Product Information
BOC-L-Isoleucine Fmoc-N-methyl-L-isoleucine Fmoc-D-Ile-OH L-allo-Isoleucine D-Alloisoleucine (2R,3R)-2-Amino-3-methylpentanoic acid