TNP 351
| 中文名称 | TNP 351 |
|---|---|
| 中文同义词 | 化合物 T26283;化合物 TNP-351 |
| 英文名称 | TNP 351 |
| 英文同义词 | TNP 351;N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]- |
| CAS号 | 125991-51-7 |
| 分子式 | C21H24N6O5 |
| 分子量 | 440.45 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 125991-51-7.mol |
| 结构式 |  |
TNP 351 性质
TNP-351 是一种抗叶酸剂。TNP-351 是一种二氢叶酸还原酶 (DHFR) 抑制剂，在体内外对白血病和实体瘤细胞均具有有效的抗肿瘤活性。
Antifolate, DHFR
TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED
50
values of 0.79 and 2.7 nM, respectively.
The ED
50
values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively.
Cell Viability Assay
| Cell Line: | L1210 and CCRF-CEM cells |
| Concentration: | 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells |
| Incubation Time: | 48 hours for L1210 cells; 72 hours for CCRF-CEM cells |
| Result: | The ED 50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively. |