AMPK-α1β1γ1 activator 1

Request For Quotation
AMPK-α1β1γ1 activator 1 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
AMPK-α1β1γ1 activator 1 Basic information
Product Name:AMPK-α1β1γ1 activator 1
Synonyms:AMPK-α1β1γ1 activator 1;β-D-Glucopyranuronic acid, 1-[6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylate]
CAS:1943510-86-8
MF:C25H24ClNO9
MW:517.91
EINECS:
Product Categories:
Mol File:1943510-86-8.mol
AMPK-α1β1γ1 activator 1 Structure
AMPK-α1β1γ1 activator 1 Chemical Properties
Boiling point 822.911±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.668±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka2.666±0.70(predicted)
Safety Information
MSDS Information
AMPK-α1β1γ1 activator 1 Usage And Synthesis
UsesAMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy[1].
References[1] Ryder TF, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Aug 23;61(16):7273-7288. DOI:10.1021/acs.jmedchem.8b00807
AMPK-α1β1γ1 activator 1 Preparation Products And Raw materials
Tag:AMPK-α1β1γ1 activator 1(1943510-86-8) Related Product Information
AMPK-α1β1γ1 activator 1 Doxorubicin hydrochloride gamma-Glu-Cys trifluoroacetate salt Metformin Tranexamic Acid 1H-Indole-5-propanamide, 3-[[4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-2,3-dihydro-2-oxo-, (3Z)-