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| | Permethrin-d9 Basic information |
| | Permethrin-d9 Chemical Properties |
| solubility | Methanol: Slightly soluble |
| | Permethrin-d9 Usage And Synthesis |
| Description | Permethrin-d9 is intended for use as an internal standard for the quantification of permethrin (Item No. 23821) by GC- or LC-MS. Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.1 It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.2 Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.3 Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.WARNING This product is not for human or veterinary use. | | References | [1] JIN-SUNG CHOI David M S. Structure–activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes[J]. Toxicology and applied pharmacology, 2006, 211 3: Pages 233-244. DOI: 10.1016/j.taap.2005.06.022
[2] J W WARMKE. Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology.[J]. Journal of General Physiology, 1997, 110 2: 119-133. DOI: 10.1085/jgp.110.2.119
[3] MUHAMMAD M HOSSAIN J R Jason Liu. Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels[J]. Toxicological Sciences, 2017, 89 1: 112-123. DOI: 10.1093/toxsci/kfw187 |
| | Permethrin-d9 Preparation Products And Raw materials |
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