5-propan-2-yl-1H-indole-2,3-dione manufacturers
- 5-Isopropyl Isatin
-
-
2025-08-27
- CAS:150560-58-0
- Min. Order: 1kg
- Purity: 98.0% min
- Supply Ability: 10tons
|
| | 5-propan-2-yl-1H-indole-2,3-dione Basic information |
| Product Name: | 5-propan-2-yl-1H-indole-2,3-dione | | Synonyms: | 5-propan-2-yl-1H-indole-2,3-dione;5-Isopropylisatin;5-Isopropylindoline-2,3-dione;11J-308S;1H-Indole-2,3-dione, 5-isopropyl-;ZINC03276921;5-isopropyl-1H-indole-2,3-dione(SALTDATA: FREE);organic chemicals : 5,5-dimethylcyclohex an-1, 3-dion | | CAS: | 150560-58-0 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | | | Product Categories: | | | Mol File: | 150560-58-0.mol |  |
| | 5-propan-2-yl-1H-indole-2,3-dione Chemical Properties |
| Melting point | 140 °C | | density | 1.200±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 9.81±0.20(Predicted) |
| Risk Statements | 36 | | Safety Statements | 26 | | RIDADR | UN 2811 6.1 / PGIII | | HS Code | 2933998090 |
| | 5-propan-2-yl-1H-indole-2,3-dione Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 5-isopropylindoline-2,3-dione using the compound (CAS: 68701-52-0) as starting material was as follows: 41.2 g of isonitrosoacetyl-p-isopropylaniline was slowly added to 294 g of 95% sulfuric acid at room temperature. Subsequently, the temperature of the reaction system was gradually increased to 30°C over a period of 10 minutes and the reaction mixture was continuously stirred at this temperature for 2 hours. Upon completion of the reaction, the reaction solution was slowly added dropwise to a separate vessel containing 419 g of water and the precipitate precipitated was subsequently collected by filtration. The precipitate was washed with 1,300 g of water and dried in a drying oven at 60 °C to yield 37.3 g of 5-isopropylisatin. The yield of this step was 98.7%, the purity of the product was 98.1% (wt%) and the melting point was 137-140 °C. In this embodiment, the molar ratio of isonitrosoacetyl-p-isopropylaniline to sulfuric acid was 1:14.3. | | References | [1] Patent: JP2018/150285, 2018, A. Location in patent: Paragraph 0024-0031; 0036
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 7, p. 1585 - 1587 |
| | 5-propan-2-yl-1H-indole-2,3-dione Preparation Products And Raw materials |
|