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| | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Basic information |
| Product Name: | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride | | Synonyms: | N-DI-DESMETHYL SIBUTRAMINE HCL;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL;1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride;Sibutramine Impurity 1;1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine,hydrochloride;N,N-Didesmethyl Sibutramine HCl;1-(4-CHLOROPHENYL)-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE | | CAS: | 84484-78-6 | | MF: | C15H23Cl2N | | MW: | 288.26 | | EINECS: | | | Product Categories: | | | Mol File: | 84484-78-6.mol | ![1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Structure](CAS/GIF/84484-78-6.gif) |
| | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties |
| Melting point | 160 - 166°C | | storage temp. | Desiccate at RT | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS DataBase Reference | 84484-78-6(CAS DataBase Reference) |
| | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Usage And Synthesis |
| Uses | Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2]. | | Biological Activity | Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis. | | in vitro | simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1]. | | in vivo | the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2]. | | IC 50 | 0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake | | references | [1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34. |
| | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials |
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