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| | CDD-1653 Basic information |
| Product Name: | CDD-1653 | | Synonyms: | CDD-1653;Benzenesulfonamide, 3-[[5-methoxy-4-(3-oxo-4-phenyl-1-piperazinyl)-2-pyrimidinyl]amino]- | | CAS: | 3034216-44-6 | | MF: | C21H22N6O4S | | MW: | 454.5 | | EINECS: | | | Product Categories: | | | Mol File: | 3034216-44-6.mol |  |
| | CDD-1653 Chemical Properties |
| Boiling point | 800.158±75.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.425±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 10.073±0.60(predicted) | | form | Solid | | color | White to yellow |
| | CDD-1653 Usage And Synthesis |
| Uses | CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1]. | | References | [1] Modukuri R K, et al. Discovery of highly potent and BMPR2-selective kinase inhibitors using DNA-encoded chemical library screening[J]. Journal of Medicinal Chemistry, 2023, 66(3): 2143-2160. DOI:10.1021/acs.jmedchem.2c01886 |
| | CDD-1653 Preparation Products And Raw materials |
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