7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-

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7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Suppliers list
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7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Basic information
Product Name:7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-
Synonyms:7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-;AD1058
CAS:2907782-78-7
MF:C19H20N6O3S
MW:412.47
EINECS:
Product Categories:
Mol File:2907782-78-7.mol
7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Structure
7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Chemical Properties
density 1.57±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.43±0.40(predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Usage And Synthesis
UsesAD1058 is an orally active, selective, and blood-brain barrier permeable inhibitor of ATR. AD1058 exhibits in vivo anticancer activity, inhibiting cell proliferation, disrupting the cell cycle, and inducing Apoptosis. AD1058 can be utilized in research on brain and central nervous system metastases stemming from advanced solid tumors[1].
IC 50ATR: 1.6 nM (IC50); mTOR: 45.83 nM (IC50); ARK5: 7314.00 nM (IC50); LCK: 2594.00 nM (IC50)
References[1] Liu Z, Jiang K, et al. Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies. J Med Chem. 2024 Aug 8;67(15):12735-12759. DOI:10.1021/acs.jmedchem.4c00734
7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Preparation Products And Raw materials
Tag:7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-(2907782-78-7) Related Product Information
7H-Pyrrolo[2,3-d]pyrimidine, 4-[(3R)-3-methyl-4-morpholinyl]-7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)- Anti-Aging Compound Library Protein Tyrosine Kinase Compound Library Anti-cancer compound library Stem Cell Signaling Compound Library Apoptosis Compound Library