2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)-

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2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- Basic information
Product Name:2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)-
Synonyms:2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)-;Dyrk1A-IN-10
CAS:2891824-14-7
MF:C22H21ClN2O2
MW:380.87
EINECS:
Product Categories:
Mol File:2891824-14-7.mol
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- Structure
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- Chemical Properties
Boiling point 630.6±55.0 °C(predicted)
density 1.287±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka16.94±0.40(predicted)
Safety Information
MSDS Information
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- Usage And Synthesis
UsesDyrk1A-IN-10 (compound B4) is a DYRK1A inhibitor with antidiabetic activity. Dyrk1A-IN-10 can promote pancreatic β-cell proliferation, increase insulin secretion, and lower blood sugar[1].
References[1] Li Guan, et al. "Design, synthesis, and biological evaluation of β-carboline-cinnamic acid derivatives as DYRK1A inhibitors in the treatment of diabetes." Bioorganic Chemistry (2024): 107676. DOI:10.1016/j.bioorg.2024.107676
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- Preparation Products And Raw materials
Tag:2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)-(2891824-14-7) Related Product Information
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- YK-2-69 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 2,6-Pyridinediamine, 4-[2-methyl-3-(2,2,2-trifluoroethyl)-3H-imidazo[4,5-b]pyridin-5-yl]- Dyrktide AZ191