3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-

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3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Basic information
Product Name:3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-
Synonyms:3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-;Sigma-1 receptor antagonist 6
CAS:1335032-28-4
MF:C32H34N6
MW:502.65
EINECS:
Product Categories:
Mol File:1335032-28-4.mol
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Structure
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Chemical Properties
Boiling point 737.3±60.0 °C(predicted)
density 1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka8.96±0.10(predicted)
Safety Information
MSDS Information
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Usage And Synthesis
UsesSigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be used in neuropathic pain animal models to alleviate mechanical allodynia induced by paclitaxel (HY-B0015)[1].
References[1] Entrena JM, et al. The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain. Bioorg Chem. 2024 Sep;150:107537. DOI:10.1016/j.bioorg.2024.107537
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Preparation Products And Raw materials
Tag:3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-(1335032-28-4) Related Product Information
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