3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one

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3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one manufacturers
3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one Basic information
Product Name:3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one
Synonyms:3-phenyl-2-sulfanylidene-1H-quinazolin-4-one;3-phenyl-2-thioxo-1H-quinazolin-4-one;3-Phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one;Quinazolin-4-one, 1,3-dihydro-3-phenyl-2-thio-;4(1H)-Quinazolinone,2,3-dihydro-3-phenyl-2-thioxo-;TIMTEC-BB SBB000936;1,3-dihydro-3-phenyl-2-thio-quinazolin-4-on;3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE
CAS:18741-24-7
MF:C14H10N2OS
MW:254.31
EINECS:242-550-6
Product Categories:quinazolinone
Mol File:18741-24-7.mol
3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one Structure
3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one Chemical Properties
Melting point 313-314°C
Boiling point 414.8±28.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
pka10.96±0.20(Predicted)
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
HS Code 2933998090
Toxicitymouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04508,
MSDS Information
3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one Usage And Synthesis
UsesPDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases[1].
References[1] Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles DOI:10.3390/ijms22063206
3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one Preparation Products And Raw materials
Preparation Products2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one
Tag:3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-one(18741-24-7) Related Product Information
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