4,5-Dihydrocyclopenta[b]thiophen-6-one

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4,5-Dihydrocyclopenta[b]thiophen-6-one manufacturers
4,5-Dihydrocyclopenta[b]thiophen-6-one Basic information
Product Name:4,5-Dihydrocyclopenta[b]thiophen-6-one
Synonyms:4,5-Dihydrocyclopenta[b]thiophen-6-one;4H-cyclopenta[b]thiophen-6(5H)-one;4H,5H,6H-cyclopenta[b]thiophen-6-one;4H-Cyclopenta[b]thiophen-6(5H);5-CHLORO-2,3-DIMET...;5-bromo-N-(2-furanylmethyl)-2-methylbenzenesulfonamide;6H-Cyclopenta[b]thiophen-6-one, 4,5-dihydro-;4,5-dihydro-6H-cyclopenta[b]thiophen-6-one
CAS:5650-52-2
MF:C7H6OS
MW:138.19
EINECS:
Product Categories:API intermediates
Mol File:5650-52-2.mol
4,5-Dihydrocyclopenta[b]thiophen-6-one Structure
4,5-Dihydrocyclopenta[b]thiophen-6-one Chemical Properties
Melting point 90-91 °C
Boiling point 239.6±9.0 °C(Predicted)
density 1.322±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
AppearanceLight yellow to yellow Solid
Safety Information
HS Code 2934999090
MSDS Information
4,5-Dihydrocyclopenta[b]thiophen-6-one Usage And Synthesis
Synthesis
3-THIEN-3-YLPROPANOIC ACID

16378-06-6

4,5-Dihydrocyclopenta[b]thiophen-6-one

5650-52-2

To a suspension of phosphorus pentoxide (P2O5, 25.4 g, 179.0 mmol) in methanesulfonic acid (100 mL) was added 3-(thiophen-3-yl)propionic acid (5.0 g, 32.0 mmol) and the reaction mixture was stirred for 1 hour at room temperature. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent: 20-30% ethyl acetate/hexane) to afford 4,5-dihydropenta[B]thiophen-6-one (1.34 g, 30% yield) as a brown solid. The structure of the product was confirmed by 1H NMR (300 MHz, MeOH): δ 8.14 (d, J = 4.8 Hz, 1H), 7.17 (d, J = 4.8 Hz, 1H), 2.94-3.15 (m, 4H); mass spectra (EI) m/z = 139.2 [M + 1]+.

References[1] European Journal of Organic Chemistry, 2004, # 21, p. 4442 - 4451
[2] Tetrahedron, 1997, vol. 53, # 12, p. 4239 - 4246
[3] Patent: US2012/225857, 2012, A1. Location in patent: Page/Page column 16
[4] Journal of Organic Chemistry, 1997, vol. 62, # 8, p. 2401 - 2408
[5] Journal of the Chemical Society, Chemical Communications, 1994, # 19, p. 2249 - 2250
Tag:4,5-Dihydrocyclopenta[b]thiophen-6-one(5650-52-2) Related Product Information
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