1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl manufacturers
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| | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl Basic information |
| Product Name: | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl | | Synonyms: | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride;Antitrypanosomal agent 1;1-Propanone1-(34-dichlorophenyl)-3-(dimethylamino)-hydrochloride;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one;Antitrypanosomal agent-1,Antitrypanosomal agent 1,T.brucei,trypanothione,inhibit,glutathione,Antitrypanosomal agent1,Inhibitor,reductase,Parasite,anti-trypanosomal;Antitrypanosomal agent 1, 10 mM in DMSO;1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl | | CAS: | 75144-12-6 | | MF: | C11H14Cl3NO | | MW: | 282.59 | | EINECS: | | | Product Categories: | | | Mol File: | 75144-12-6.mol |  |
| | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl Chemical Properties |
| Melting point | 186 - 188°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White | | Water Solubility | Water: 10 mg/mL (35.39 mM) |
| | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl Usage And Synthesis |
| Uses | Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1]. | | Biological Activity | Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity. | | in vitro | Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20. | | target | IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)
EC50: 1 μM ( T. brucei ) | | References | [1] Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3. DOI:10.1016/j.bmcl.2006.12.016 |
| | 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl Preparation Products And Raw materials |
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