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| | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE Basic information |
| Product Name: | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE | | Synonyms: | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE;2-Amine-5-Fluorothiazol HCL;2-Amino-5-fluoro-1,3-thiazole hydrochloride;5-Fluoro-1,3-thiazol-2-amine hydrochloride;2-AMino-5-fluorothiazole HCl;5-Fluorothiazole-2-aMine hydrochloride;5-Fluorothiazol-2-aMine HCl;5-Fluroro-2-thiazolaMine hydrochloride | | CAS: | 745053-64-9 | | MF: | C3H3FN2S.HCl | | MW: | 154.59 | | EINECS: | | | Product Categories: | | | Mol File: | 745053-64-9.mol |  |
| | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE Chemical Properties |
| Melting point | 138-143°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | Appearance | Yellow to brown Solid | | InChI | 1S/C3H3FN2S.ClH/c4-2-1-6-3(5)7-2;/h1H,(H2,5,6);1H | | InChIKey | HUXNGTYNEWXYDM-UHFFFAOYSA-N | | SMILES | Cl.Nc1ncc(F)s1 | | CAS DataBase Reference | 745053-64-9 |
| WGK Germany | 3 | | HS Code | 2934100090 | | Storage Class | 11 - Combustible Solids |
| | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE Usage And Synthesis |
| Uses | 5-Fluorothiazol-2-amine Hydrochloride can be used as anti-tumor agents. | | Synthesis | b) Synthesis of 5-fluorothiazol-2-amine hydrochloride; N-(5-fluoro-2-thiazolyl)-carbamic acid-1,1-dimethylethyl ester (4.6 g, 21.1 mmol) was dissolved in dioxane (25 mL). HCl gas was passed into the solution for 4 h. Subsequently, ether (50 mL) was added to form a suspension and the solid was collected by filtration. The resulting solid was dried under high vacuum to give 5-fluorothiazol-2-amine hydrochloride (3.03 g, 19.7 mmol, 93% yield). The product was confirmed by 1H NMR (D2O): δ 7.00 (1H, d); mass spectrometry analysis showed m/z = 119.0 [M + H]+. | | References | [1] Organic Process Research and Development, 2006, vol. 10, # 2, p. 346 - 348
[2] Patent: WO2006/16178, 2006, A1. Location in patent: Page/Page column 9
[3] Patent: WO2006/16174, 2006, A1. Location in patent: Page/Page column 17
[4] Patent: EP2105435, 2009, A1. Location in patent: Page/Page column 54-55
[5] Patent: WO2012/51450, 2012, A1. Location in patent: Page/Page column 28 |
| | 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE Preparation Products And Raw materials |
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