2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt)

Request For Quotation
2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Basic information
Product Name:2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt)
Synonyms:2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt);2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Structure
2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Chemical Properties
solubility Water: soluble
Safety Information
MSDS Information
2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Usage And Synthesis
Description2'-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (2’-MANT-ADP) and 3’-MANT-ADP are fluorescent ADP derivatives, which undergo spontaneous isomerization.1 2’(3’)-MANT-ADP selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 250, 1,500, 270, and 380 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 400 nM), and B. anthracis edema factor AC toxin (Ki = 450 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 15 and 18 µM, respectively). Formation of 2’(3’)-MANT-ADP from 2’(3’)-MANT-ATP (Item No. 38467) has been used to quantify the activity of the ATPase kinesin.2 A related derivative, 2'(3')-MANT-ATP (Item No. 38469), displays an emission maximum of 446 nm upon excitation at 350 nm.3WARNING This product is not for human or veterinary use.
References[1] ANDREAS GILLE. Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.[J]. The Journal of Biological Chemistry, 2004, 279 19: 19955-19969. DOI: 10.1074/jbc.m312560200
[2] Y. Z. MA  Edwin W T. Mechanism of Microtubule Kinesin ATPase[J]. Biochemistry Biochemistry, 1995, 34 40: 13242-13251. DOI: 10.1021/bi00040a040
[3] HIRATSUKA T. New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes[J]. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983, 742 3: Pages 496-508. DOI: 10.1016/0167-4838(83)90267-4
2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Preparation Products And Raw materials
Tag:2'(3')-O-(N'-Methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) Related Product Information
2'(3')-O-(N'-Methylanthraniloyl)guanosine-5'-O-diphosphate (sodium salt) 2'-Deoxy-3'-O-(N'-methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt) 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) 2'-Deoxy-3'-O-(N'-methylanthraniloyl)adenosine-5'-O-triphosphate (sodium salt) 2'(3')-O-(N-Methylanthraniloyl)adenosine-5'-O-triphosphate (sodium salt)