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| | β-Endorphin (rat) (trifluoroacetate salt) Basic information |
| | β-Endorphin (rat) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | β-Endorphin (rat) (trifluoroacetate salt) Usage And Synthesis |
| Description | β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.1 It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and Δ-opioid antagonist ICI 174,864.2 In vivo, β-EP (5 μg, i.c.v.) slows gastrointestinal transit in mice. β-EP (0.5 or 5 μg, i.c.v.) stimulates food intake in rats for 4 to 6 hours, however, this effect is not prolonged with continuous infusion.3 It antagonizes the appetite-suppressive effects of α-melanocyte-stimulating hormone (α-MSH) for the first three days post administration. β-EP also reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent, but not irradiated or immune-incompetent, mice and rats.4WARNING This product is not for human or veterinary use. | | References | [1] H. M. D. R. HERATH. Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography–tandem mass spectrometric analysis[J]. Analytical and Bioanalytical Chemistry, 2012, 402 6: 2089-2100. DOI: 10.1007/s00216-011-5686-8
[2] J E SHOOK. Opioid receptor selectivity of beta-endorphin in vitro and in vivo: mu, delta and epsilon receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1988, 246 3: 1018-1025.
[3] ROXANNE DUTIA. β-Endorphin antagonizes the effects of α-MSH on food intake and body weight.[J]. Endocrinology, 2012, 153 9: 4246-4255. DOI: 10.1210/en.2012-1166
[4] WENDY GILMORE Doris S M. β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM[J]. Journal of neuroimmunology, 1993, 48 1: Pages 81-90. DOI: 10.1016/0165-5728(93)90061-3 |
| | β-Endorphin (rat) (trifluoroacetate salt) Preparation Products And Raw materials |
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