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| | Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt) Basic information |
| | Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt) Usage And Synthesis |
| Description | Oxyntomodulin is a peptide hormone involved in regulation of food intake, energy expenditure, and glucose metabolism.1 It is produced in gut endocrine L-cells via post-translational processing of preproglucagon by prohormone convertase 1/3 following nutrient uptake. Oxyntomodulin is an agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR; IC50s = 4.3 and 355 nM for rat GCGR and GLP-1R, respectively).2 It is selective for GCGR and GLP-1R over GLP-2R and glucose-dependent insulinotrophic peptide receptor (GIPR), as it stimulates cAMP formation in BHK cells expressing rat GCGR and GLP-1R when used at concentrations of 10 or 100 nM, but has no effect on cells expressing rat GLP-2R or GIPR at either concentration.3 Oxyntomodulin also stimulates cAMP formation in CHO cells expressing mouse GLP-1R and GCGR (EC50s = 2.5 and 6.2 nM, respectively).4 In vivo, oxyntomodulin reduces refeeding in 24-hour fasted rats when injected intracerebroventricularly or into the paraventricular nucleus (PVN) of the hypothalamus at doses of 3 and 1 nmol, respectively.5 Oxyntomodulin (50 nmol/kg twice per day for 7 days) reduces cumulative daily food intake and rate of body weight gain in rats.6WARNING This product is not for human or veterinary use. | | References | [1] POCAI A. Action and therapeutic potential of oxyntomodulin[J]. Molecular Metabolism, 2014, 3 3: Pages 241-251. DOI: 10.1016/j.molmet.2013.12.001
[2] SAMANTHA L. PRICE MRES Stephen R B M James S Minnion PhD. Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats[J]. Current Therapeutic Research-clinical and Experimental, 2015, 77: Pages 111-115. DOI: 10.1016/j.curtheres.2015.10.003
[3] LAURIE L. BAGGIO . Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure[J]. Gastroenterology, 2004, 127 2: Pages 546-558. DOI: 10.1053/j.gastro.2004.04.063
[4] ALESSANDRO POCAI. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.[J]. Diabetes, 2009, 58 10: 2258-2266. DOI: 10.2337/db09-0278
[5] C. DAKIN. Oxyntomodulin inhibits food intake in the rat.[J]. Endocrinology, 2001, 11 1: 4244-4250. DOI: 10.1210/endo.142.10.8430
[6] CATHERINE L DAKIN. Peripheral oxyntomodulin reduces food intake and body weight gain in rats.[J]. Endocrinology, 2004, 145 6: 2687-2695. DOI: 10.1210/en.2003-1338 |
| | Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt) Preparation Products And Raw materials |
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