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| | (3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER Basic information |
| Product Name: | (3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER | | Synonyms: | 3-(DIETHYLPHOSPHONOMETHYL)ANISOLE;(3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER;Diethyl 3-Methoxybenzyl phosphonate, 98 %;m-Methoxybenzylphosphonic acid diethyl ester;Diethyl 3-methoxyben;3-(Diethylphosphonomethyl)anisole
(3-Methoxybenzyl)phosphonic Acid Diethyl Ester;diethyl [(3-Methoxyphenyl)Methyl]phosphonate;DIETHYL (3-METHOXYBENZYL)PHOSPHONATE | | CAS: | 60815-18-1 | | MF: | C12H19O4P | | MW: | 258.25 | | EINECS: | | | Product Categories: | | | Mol File: | 60815-18-1.mol |  |
| | (3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER Chemical Properties |
| Boiling point | 135 °C / 0.5mmHg | | density | 1.13 | | refractive index | 1.5020-1.5060 | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | Chloroform (Sparingly) | | form | Oil | | color | Colourless | | Stability: | Moisture Sensitive | | CAS DataBase Reference | 60815-18-1 |
| | (3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER Usage And Synthesis |
| Synthesis | Step 1: A mixture of triethyl phosphite (1.45 g, 8.70 mmol) and 1-(bromomethyl)-3-methoxybenzene (1.50 g, 7.50 mmol) was stirred and reacted at 90 °C overnight under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature to afford the yellow oily product diethyl 3-methoxybenzylphosphonate (1.84 g, 95.9% yield). The product did not require further purification and could be used directly in the next step of the reaction. The product was characterized by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 259.2 ([M + H]+); exact mass of molecular formula C12H19O4P: 258.10. | | References | [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 7724 - 7730
[2] Patent: WO2015/90232, 2015, A1. Location in patent: Paragraph 00246
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7444 - 7447
[4] Journal of the American Chemical Society, 1976, vol. 98, # 18, p. 5574 - 5581
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 4, p. 1292 - 1295 |
| | (3-METHOXYBENZYL)PHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials |
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