| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Pronethalol hydrochloride;2-IsopropylaMino-1-(2-naphthyl)ethanolhydrochloride
CAS:51-02-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Pronethalol hydrochloride
CAS:51-02-5
Purity:>=99% by HPLC Remarks:Reach out to us for more information about custom solutions.
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2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE manufacturers
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| | 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Basic information |
| Product Name: | 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE | | Synonyms: | PRONETHALOL HYDROCHLORIDE;2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE;PronethalolHCl;1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride;alderlinhydrochloride;alpha-(((1-methylethyl)amino)methyl)-2-naphthalenemethanol,hydrochloride;alpha-((isopropylamino)methyl)-2-naphthalenemethanolhydrochloride;alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride | | CAS: | 51-02-5 | | MF: | C15H20ClNO | | MW: | 265.78 | | EINECS: | | | Product Categories: | | | Mol File: | 51-02-5.mol |  |
| | 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Chemical Properties |
| Melting point | 184° | | storage temp. | Store at RT | | form | Powder | | Water Solubility | Soluble to 100 mM in water | | IARC | 3 (Vol. 13, Sup 7) 1987 | | EPA Substance Registry System | Pronetalol hydrochloride (51-02-5) |
| Toxicity | LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black) |
| | 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Usage And Synthesis |
| Uses | Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2]. | | Definition | ChEBI: Pronetalol hydrochloride is an organic molecular entity. | | Biological Activity | β -adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias. | | in vivo | Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].
| | IC 50 | β adrenergic receptor | | References | [1] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. DOI:10.1016/0002-8703(66)90217-1
[2] Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. DOI:10.1172/JCI125965
[3] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508. |
| | 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE Preparation Products And Raw materials |
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