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| | 1-Amino-4-methylpiperazine Basic information |
| | 1-Amino-4-methylpiperazine Chemical Properties |
| Boiling point | 172-175 °C (lit.) | | density | 0.957 g/mL at 25 °C (lit.) | | vapor pressure | 1.29hPa at 25℃ | | refractive index | 1.4835-1.4855 | | Fp | 62 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | water: soluble | | form | Viscous Solution | | pka | 7+-.0.42(Predicted) | | color | Clear | | Water Solubility | miscible | | Sensitive | Air & Light Sensitive | | BRN | 103334 | | InChI | 1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3 | | InChIKey | RJWLLQWLBMJCFD-UHFFFAOYSA-N | | SMILES | CN1CCN(N)CC1 | | LogP | -1.61 at 25℃ | | CAS DataBase Reference | 6928-85-4(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Amino-4-methylpiperazine(6928-85-4) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 24/25-36-26 | | RIDADR | 2733 | | WGK Germany | 3 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29335995 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-Amino-4-methylpiperazine Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | 1-Amino-4-methylpiperazine has been used:
in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-amine
synthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-amine
synthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-amine
synthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-amine
synthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-amine
synthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine | | Application | 1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease. | | Preparation | 1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine. | | Flammability and Explosibility | Not classified |
| | 1-Amino-4-methylpiperazine Preparation Products And Raw materials |
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