|
|
| | (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine Basic information |
| | (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine Chemical Properties |
| Boiling point | 98-112℃/1mm | | density | 1.044±0.06 g/cm3(Predicted) | | refractive index | 1.4670-1.4710 | | storage temp. | 2-8°C | | solubility | Miscible with N-methylpyrrolidinone. | | form | clear liquid | | pka | 9.91±0.29(Predicted) | | color | Colorless to Almost colorless | | BRN | 8905233 | | InChI | 1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(12)7-11/h8H,4-7,11H2,1-3H3/t8-/m0/s1 | | InChIKey | SOGXYCNKQQJEED-QMMMGPOBSA-N | | SMILES | CC(C)(C)OC(=O)N1CCC[C@H]1CN | | CAS DataBase Reference | 119020-01-8(CAS DataBase Reference) |
| Hazard Codes | Xi,N,C | | Risk Statements | 36/37/38-51/53-34-22 | | Safety Statements | 26-36/37/39-61-45 | | RIDADR | 3259 | | WGK Germany | 3 | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 29339900 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Skin Corr. 1B |
| | (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine Usage And Synthesis |
| Description | (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine is an optically active compound primarily used in organic synthesis for preparing small-molecule protein synthesis regulators or molecular glue degraders. | | Chemical Properties | Solid | | Uses | (S)-2-Aminomethyl-1-Boc-pyrrolidine acts as an intermediate in organic synthesis. It is also used as a chiral and heterocyclic building block in synthetic chemistry. | | Synthesis | GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with an eluent ratio of methanol-dichloromethane (9:1). | | References | [1] Synthesis, 2005, # 14, p. 2407 - 2413
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11382 - 11385
[3] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[4] Tetrahedron Letters, 2010, vol. 51, # 40, p. 5281 - 5286
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2013, vol. 188, # 4, p. 509 - 511 |
| | (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine Preparation Products And Raw materials |
|