GR 127935 HYDROCHLORIDE
| 中文名称 | GR 127935 HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T22806;N-(4-甲氧基-3-(4-甲基哌嗪-1-基)苯基)-2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)-[1,1'-联苯]-4-甲酰胺盐酸盐;化合物 GR 127935 HYDROCHLORIDE;GR 127935 HYDROCHLORIDE,5-HT1B/1D RECEPTOR拮抗剂 |
| 英文名称 | N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride |
| 英文同义词 | GR 127935 hydrate hydrochloride;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride;GR-127935 hydrochloride (GR127935);N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrochloride hydrate;GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist;N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride |
| CAS号 | 148642-42-6 |
| 分子式 | C29H31N5O3·HCl |
| 分子量 | 534.1 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 148642-42-6.mol |
| 结构式 |  |
GR 127935 HYDROCHLORIDE 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 100 mM in water |
| InChIKey | KSXUSAQPMSACQS-UHFFFAOYSA-N |
| SMILES | O.Cl.COc1ccc(NC(=O)c2ccc(cc2)-c3ccc(cc3C)-c4noc(C)n4)cc1N5CCN(C)CC5 |
GR127935 hydrochloride 是一种有效且具有口服活性的 5-HT1D 和 5-HT1B 受体拮抗剂，pKi 值均为 8.5。GR127935 hydrochloride 对 5-HT1B/1D 受体的选择性是 5-HT1A、5-HT2A 和 5-HT2C 受体的 100 倍。GR127935 hydrochloride 可用于神经疾病研究。
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100794 | GR 127935 HYDROCHLORIDE HYDRATE GR127935 hydrochloride | 148642-42-6 | 1 mg | 700元 |
| 2026/06/05 | HY-100794 | GR 127935 HYDROCHLORIDE HYDRATE GR127935 hydrochloride | 148642-42-6 | 5 mg | 1430元 |