| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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| Products Intro: |
Product Name:D-erythro-Dihydro-D-sphingosine-1-phosphate
CAS:19794-97-9
Package:50Mg,5Mg
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:D-erythro-Dihydrosphingosine 1-phosphate
CAS:19794-97-9
Purity:98% (TLC) Package:5MG; 25MG; 100MG; 1G
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| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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| Tel: |
0717-6449896 13886658719 |
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root@zhongyitai.com |
| Products Intro: |
Product Name:D-erythro-Dihydrosphingosine-1-phosphate
CAS:19794-97-9
Purity:98+% Package:5mg
|
| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
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| Tel: |
15221275939 15221275939 |
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shenlinxing@macklin.cn |
| Products Intro: |
Product Name:Sphinganine-1-phosphate (d18:0)
CAS:19794-97-9
Purity:98% Package:1mg
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| | (2-amino-3-hydroxy-octadecoxy)phosphonic acid Basic information |
| Product Name: | (2-amino-3-hydroxy-octadecoxy)phosphonic acid | | Synonyms: | SPHINGANINE-1-PHOSPHATE;(2-amino-3-hydroxy-octadecoxy)phosphonic acid;dihydrosphingosine 1-phosphate;D-erythro-sphinganine-1-phosphate;(2S,3R)-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate);(2S,3R)-Sphinganine 1-Phosphate;[R-(R*,S*)]-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate);C18-Dihydrosphingosine 1-Phosphate | | CAS: | 19794-97-9 | | MF: | C18H40NO5P | | MW: | 381.49 | | EINECS: | | | Product Categories: | | | Mol File: | 19794-97-9.mol |  |
| | (2-amino-3-hydroxy-octadecoxy)phosphonic acid Chemical Properties |
| Boiling point | 548.2±60.0 °C(Predicted) | | density | 1.080±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | 0.3 M NaOH: 4 mg/ml; DMF: <50 μg/ml; DMSO: <50 μg/ml; Ethanol: <50 μg/ml; PBS (pH 7.2): <50 μg/ml | | form | A crystalline solid | | pka | 1.76±0.10(Predicted) | | color | White to off-white | | InChI | 1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1 | | InChIKey | YHEDRJPUIRMZMP-ZWKOTPCHSA-N | | SMILES | CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | (2-amino-3-hydroxy-octadecoxy)phosphonic acid Usage And Synthesis |
| Chemical Properties | White to Beige Solid | | Uses | (2-amino-3-hydroxy-octadecoxy)phosphonic acid may be used as a negative control for C2 Ceramide. | | Definition | ChEBI: A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine. | | Biochem/physiol Actions | Negative control for sphingosine-1-phosphate. | | in vivo | Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1].
Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2]. | Animal Model: | Male C57BL/6 mice (20-25g)[2] | | Dosage: | 0.1mg/kg | | Administration: | Administered i.v. immediately before reperfusion and 0.2mg/kg s.c. 2 h after reperfusion | | Result: | The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557U/L) and Cr (0.55±0.05mg/dL) were significantly suppressed at 24h after reperfusion in mice treated with 0.1mg/kg i.v. before reperfusion and 0.2mg/kg s.c. 2h after reperfusion.
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| | IC 50 | Human Endogenous Metabolite |
| | (2-amino-3-hydroxy-octadecoxy)phosphonic acid Preparation Products And Raw materials |
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