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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Suppliers list
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| Company Name: |
Lynnchem |
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Company Name: |
Novachemistry |
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione manufacturers
- Setomimycin
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- $198.00
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2026-07-27
- CAS:69431-87-4
- Purity: 92.81%
- Supply Ability: 10g
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| | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Basic information |
| Product Name: | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione | | Synonyms: | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione;A-39183B;Antibiotic A-39183B;Setomimycin;SetoMiMycin [SetoMiMicin];AM 2947;AM2947;AM-2947 | | CAS: | 69431-87-4 | | MF: | C34H28O9 | | MW: | 580.58 | | EINECS: | | | Product Categories: | | | Mol File: | 69431-87-4.mol | ![1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Structure](CAS/GIF/69431-87-4.gif) |
| | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Chemical Properties |
| Boiling point | 765.2±60.0 °C(Predicted) | | density | 1.479±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: soluble; DMSO: soluble | | form | A solid | | pka | 3.61±0.60(Predicted) |
| | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Usage And Synthesis |
| Uses | Setomimycin is a rare 9,9’-bianthryl antibiotic first isolated from a strain of Streptomyces pseudovenezuelae by Omura and colleagues at the Kitasato Institute, Japan, in 1978. Setomimycin is active against Gram positive bacteria, including mycobacteria, and has antitumor activity both in vitro and in vivo. Limited access has restricted further research on this metabolite. | | Uses | Setomimycin is an antibiotic that is active against Gram positive bacteria, including mycobacteria. | | in vivo | Setomimycin (20 mg/kg; i.p.; alternate days for two weeks) shows antitumor activity in mice[2]. Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].
| Pharmacokinetic parameters | Value | | Cmax (ng/ml) | 694 ± 62 | | Tmax (h) | 0.3 ± 0.1 | | T1/2 (h) | 2.3 ± 0.5 | | AUC0-t (ng.h/mL) | 2613 ± 111 | | AUC0-α (ng.h/mL) | 2734 ± 108 | | Vd (L/Kg) | 24 ± 4 | | Cl (L/h/Kg) | 7.4 ± 0.3 |
Female BALB/c mice, 20 mg/kg ip (1 % DMSO +30 % PEG-200 + 2 % Tween 80 + q.s. water (v/v)) [2]| Animal Model: | 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2] | | Dosage: | 20 mg/kg | | Administration: | I.p.; every other day for two weeks | | Result: | Decreased primary tumor weight (76%) and volume (90.5%). |
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| | 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Preparation Products And Raw materials |
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