Product Details
| Product Name:
Setomimycin |
CAS No.:
69431-87-4 |
| Purity:
92.81% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | Setomimycin |
| Description | Setomimycin is a potent antibiotic compound that inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 12.02 μM, and also exhibits anti-inflammatory, antioxidant, antiproliferative, and antitumor activities, enabling multidisciplinary research spanning antiviral drug discovery, inflammation biology, and cancer pharmacology. |
| In vitro | In enzymatic assays, Setomimycin inhibited SARS-CoV-2 Mpro with an IC50 of 12.02 μM. In cellular models, it inhibited NO and cytokine release in LPS-stimulated macrophages (0.01-1 μM), showed antibacterial activity against Gram-positive bacteria (MIC 4-16 μg/mL), and inhibited cancer cell proliferation (IC50 4.57-48 μM) by modulating p-MEK/p-ERK/Bcl-2/Par-4 levels [1]. |
| In vivo | In a 4T1 mouse breast cancer model using BALB/c mice, intraperitoneal (i.p.) administration of Setomimycin (20 mg/kg, every other day) for two weeks reduced primary tumor growth. The treatment resulted in a 76% reduction in tumor weight and a 90.5% reduction in tumor volume compared to the control group [2]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Setomimycin |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Molnupiravir | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Chloroquine phosphate | Chloroquine | α-Cyclodextrin | Dexamethasone | Bromhexine hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States