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| | 3-(4-Iodo-phenyl)-1-(4'-boranyl-phenyl)-prop-2-enone Basic information |
| | 3-(4-Iodo-phenyl)-1-(4'-boranyl-phenyl)-prop-2-enone Chemical Properties |
| storage temp. | +2C to +8C | | solubility | DMSO: >30 mg/mL, soluble | | form | solid | | color | pale yellow | | InChI | 1S/C15H12BIO3/c17-14-8-1-11(2-9-14)3-10-15(18)12-4-6-13(7-5-12)16(19)20/h1-10,19-20H/b10-3+ | | InChIKey | BYMGWCQXSPGCMW-XCVCLJGOSA-N |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 3-(4-Iodo-phenyl)-1-(4'-boranyl-phenyl)-prop-2-enone Usage And Synthesis |
| Uses | TLBC, a boronic-chalcone derivative, shows a dose-dependent inhibition with IC50 values of 5.5-25.5 μM in various glioma cell lines. TLBC induces apoptosis independent of changes to the tumor suppressor p53[1]. | | Definition | ChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones. | | General Description | A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 μM for MCF-10A and 63 μM for MCF-12A). | | Biochem/physiol Actions | Cell permeable: yes | | References | [1] Takashi Sasayama, et al. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. J Neurooncol. 2007 Nov;85(2):123-32. DOI:10.1007/s11060-007-9395-2 |
| | 3-(4-Iodo-phenyl)-1-(4'-boranyl-phenyl)-prop-2-enone Preparation Products And Raw materials |
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