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- Pyrenophorol
-
- $668.00
-
2026-05-11
- CAS:22248-41-5
- Purity:
- Supply Ability: 10g
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| | (-)-Pyrenophorol Basic information |
| Product Name: | (-)-Pyrenophorol | | Synonyms: | (-)-Pyrenophorol;(3E,5S,8R,11E,13S,16R)-5,13-Dihydroxy-8,16-dimethyl-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;(3E,5S,8R,11E,13S,16R)-;(-)-5,13-Dihydroxy-8,16-dimethyl-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 5,13-dihydroxy-8,16-dimethyl-, (3E,5S,8R,11E,13S,16R)-;(-)-Pyrenophorol;Pyrenophorol | | CAS: | 22248-41-5 | | MF: | C16H24O6 | | MW: | 312.36 | | EINECS: | | | Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 22248-41-5.mol |  |
| | (-)-Pyrenophorol Chemical Properties |
| Melting point | 136-138℃ | | storage temp. | Store at -20°C | | solubility | DMSO: 5 mg/ml; Methanol: 5 mg/ml | | form | A solid |
| | (-)-Pyrenophorol Usage And Synthesis |
| Description | Pyrenophorol is a fungal metabolite that has been found in Alternaria and has diverse biological activities. It inhibits human topoisomerase II α when used at concentrations of 75 and 100 μM. It is active against S. cerevisiae (MIC = 4 μM) and M. violaceum. Pyrenophorol induces leaf necrosis and chlorophyll retention in wild oats when used at a concentration of 64 μM. | | Uses | The macrolide dilactone Pyrenophorol
n anti-fungal antibiotic produced by the plant pathogenic fungi Pyrenophora avenue and Stemphylium radicinum, which is closely related structurally to (-)-
Pyrenophorol | | Uses | Pyrenophorol is a simple macrocyclic dilactone produced by a number of species of pathogenic fungi, including Byssochlamys, Stenphyllum, Alternaria and Drechslera, first reported in the late 1960s. Pyrenophorol exhibits antibiotic, herbicidal and anthelmintic properties, and is a weak inhibitor of propyl endopeptidases. Pyrenophorol inhibits seed germination but once the seed is germinated, pyrenophlorol enhances root development but causes abnormal chlorophyll retention in leaf sections. | | Uses | The macrolide dilactone Pyrenophorol was originally isolated from Byssochlamys niveah and Stemphylium radicinum. Pyrenophorol was moderately active against the fungus Microbotryum violaceum. It is an anti-fungal antibiotic produced by the plant pathogenic fungi Pyrenophora avenue and Stemphylium radicinum, which is closely related structurally to (-)-Pyrenophorol. | | Definition | ChEBI: Pyrenophorol is a macrolide. | | References | [1] KATHARINA JAROLIM. Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase[J]. Archives of Toxicology, 2016, 91 4: 2007-2016. DOI: 10.1007/s00204-016-1855-z
[2] MARK W. SUMARAH . Antifungal metabolites from fungal endophytes of Pinus strobus[J]. Phytochemistry, 2011, 72 14: Pages 1833-1837. DOI: 10.1016/j.phytochem.2011.05.003
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
| | (-)-Pyrenophorol Preparation Products And Raw materials |
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