5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid

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5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid manufacturers

  • nTZDpa
  • nTZDpa pictures
  • $826.00
  • 2026-07-27
  • CAS:118414-59-8
  • Purity:
  • Supply Ability: 10g
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Basic information
Product Name:5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
Synonyms:NTZDPA;5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-;5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
CAS:118414-59-8
MF:C22H15Cl2NO2S
MW:428.33
EINECS:
Product Categories:Intracellular receptor;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:118414-59-8.mol
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Structure
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Chemical Properties
storage temp. Store at +4°C
solubility DMSO: soluble15mg/mL, clear
form powder
color white to beige
InChI1S/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27)
InChIKeyVUPOTURDKDMIGQ-UHFFFAOYSA-N
SMILESS(c4ccccc4)c1c2c([n](c1C(=O)O)Cc3ccc(cc3)Cl)ccc(c2)Cl
Safety Information
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Usage And Synthesis
UsesnTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.
Biological ActivityPotent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .
storageStore at +4°C
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Preparation Products And Raw materials
Tag:5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid(118414-59-8) Related Product Information
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