17β-Hydroxy-5α-androstane-3,11-dione manufacturers
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| | 17β-Hydroxy-5α-androstane-3,11-dione Basic information |
| Product Name: | 17β-Hydroxy-5α-androstane-3,11-dione | | Synonyms: | 17β-Hydroxy-5α-androstane-3,11-dione;5alpha-Androstane-3,11-dione-17beta-ol;11-Ketodihydrotestosterone;17beta-Hydroxy-5alpha-androstane-3,11-dione;5.alpha.-dihydro-11-keto Testosterone;5α-dihydro-11-keto Testosterone;11-KDHT;Androstane-3,11-dione, 17-hydroxy-, (5α,17β)- | | CAS: | 32694-37-4 | | MF: | C19H28O3 | | MW: | 304.43 | | EINECS: | | | Product Categories: | | | Mol File: | 32694-37-4.mol |  |
| | 17β-Hydroxy-5α-androstane-3,11-dione Chemical Properties |
| Boiling point | 453.4±45.0 °C(Predicted) | | density | 1.152±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | pka | 14.82±0.60(Predicted) | | color | White to off-white |
| | 17β-Hydroxy-5α-androstane-3,11-dione Usage And Synthesis |
| Description | 5α-dihydro-11-keto Testosterone is an analytical reference standard that is structurally classified as a steroid hormone. It is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone . The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells. This product is intended for forensic and research applications. | | Uses | 11-Ketodihydrotestosterone is a naturally occurring steroid and androgen prohormone that is produced primarily, if not exclusively, in the adrenal glands. | | references | [1]. bloem lm, storbeck kh, schloms l, et al. 11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function. molecules. 2013 oct 25;18(11):13228-44.
[2]. swart ac, storbeck kh. 11β-hydroxyandrostenedione: downstream metabolism by 11βhsd, 17βhsd and srd5a produces novel substrates in familiar pathways. mol cell endocrinol. 2015 jun 15;408:114-23.
[3]. storbeck kh, bloem lm, africander d, et al. 11β-hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel c19 steroids with androgenic activity: a putative role in castration resistant prostate cancer mol cell endocrinol. 2013 sep 5;377(1-2):135-46. |
| | 17β-Hydroxy-5α-androstane-3,11-dione Preparation Products And Raw materials |
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