梓醇 6-咖啡酸酯
| 中文名称 | 梓醇 6-咖啡酸酯 |
|---|---|
| 中文同义词 | 梓醇 6-咖啡酸酯;化合物 T13296;化合物 Verminoside;Verminoside #天然产物 HY-N1094;Verminoside #天然产物 HY-N1094 |
| 英文名称 | [(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside |
| 英文同义词 | [(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside;Vermiside;Caffeoyl catalpol;Catalpol 6-caffeate;β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-6-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl;(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside;Verminoside |
| CAS号 | 50932-19-9 |
| 分子式 | C24H28O13 |
| 分子量 | 524.47 |
| EINECS号 | |
| 相关类别 | 环烯醚萜;标准品 -中药标准品;标准品 |
| Mol文件 | 50932-19-9.mol |
| 结构式 |  |
梓醇 6-咖啡酸酯 性质
| 沸点 | 820.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.69±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.31±0.10(Predicted) |
Verminoside 是从 Kigelia africana 分离出的一种环烯醚萜，具有抗炎和显着的抗氧化活性，其自由基清除活性为 2.5 μg/mL。Verminoside 对人淋巴细胞的遗传毒性与 PARP-1 和 p53 蛋白水平升高有关。
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PARP-1
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Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.
Western Blot Analysis
| Cell Line: | J774.A1 macrophages |
| Concentration: | 0.01 mM, 0.1 mM or 1 mM |
| Incubation Time: | 25 hours |
| Result: | Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages. |