4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol

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4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol manufacturers

  • VRT-532
  • VRT-532 pictures
  • $67.00
  • 2026-05-11
  • CAS:38214-71-0
  • Purity: 99.93%
  • Supply Ability: 10g
4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol Basic information
Product Name:4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol
Synonyms:PHENOL, 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)-;CFpot 532;VRT-532;VRT-532 >=98% (HPLC);VRT 532,VRT532;VRT-532, 10 mM in DMSO;4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol
CAS:38214-71-0
MF:C16H14N2O
MW:250.3
EINECS:
Product Categories:
Mol File:38214-71-0.mol
4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol Structure
4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol Chemical Properties
Melting point 153-154 °C(Solv: acetic acid (64-19-7))
Boiling point 472.9±40.0 °C(Predicted)
density 1.213±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >20mg/mL
form solid
pka9.16±0.43(Predicted)
color White to off-white
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 2
MSDS Information
4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol Usage And Synthesis
UsesVRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].
References[1] Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. DOI:10.1042/BJ20081424
[2] Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. DOI:10.1074/jbc.C700175200
4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol Preparation Products And Raw materials
Raw materials2-Propyn-1-one, 1-(2-hydroxy-5-methylphenyl)-3-phenyl--->1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
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