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| | TIPLIMOTIDE Basic information |
| Product Name: | TIPLIMOTIDE | | Synonyms: | TIPLIMOTIDE;L-Proline, D-alanyl-L-lysyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-phenylalanyl-L-alanyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-L-threonyl- | | CAS: | 178823-49-9 | | MF: | C87H142N24O21 | | MW: | 1860.21 | | EINECS: | | | Product Categories: | | | Mol File: | 178823-49-9.mol |  |
| | TIPLIMOTIDE Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | pka | 3.39±0.20(Predicted) |
| | TIPLIMOTIDE Usage And Synthesis |
| Uses | Tiplimotide (NBI-5788) is an altered peptide ligand (APL) designed from an immunodominant region (83-99) of the neuroantigen myelin basic protein (MBP). Tiplimotide can selectively reduce the production of inflammatory cytokines by pathogenic T-cells. Tiplimotide can be used for the research of multiple sclerosis (MS)[1][2]. | | References | [1] P D Crowe, et al. NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000 Nov;48(5):758-65. PMID:11079539
[2] Maria Katsara, et al. A double mutation of MBP(83-99) peptide induces IL-4 responses and antagonizes IFN-gamma responses. J Neuroimmunol. 2008 Aug 30;200(1-2):77-89. DOI:10.1016/j.jneuroim.2008.06.013 |
| | TIPLIMOTIDE Preparation Products And Raw materials |
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