1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide

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1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Suppliers list
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1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide manufacturers

  • LY 393558
  • LY 393558 pictures
  • $575.00
  • 2026-07-15
  • CAS:271780-64-4
  • Purity:
  • Supply Ability: 10g
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Basic information
Product Name:1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide
Synonyms:1H-2,1,3-BENZOTHIADIAZINE, 1-[2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]ETHYL]-3,4-DIHYDRO-3-(1-METHYLETHYL)-6-(METHYLSULFONYL)-, 2,2-DIOXIDE;1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide;LY-393558;1-{2-[4-(6-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-1(2H)-Pyridinyl]Ethyl}-3-Isopropyl-6-(Methylsulfonyl)-3,4-Dihydro-1H-2,1,3-Benzothiadia zine 2,2-Dioxide;1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2λ6,1,3-benzothiadiazine 2,2-dioxide;Zymosan (ZM), 95%;1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide
CAS:271780-64-4
MF:C26H31FN4O4S2
MW:546.68
EINECS:
Product Categories:
Mol File:271780-64-4.mol
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Structure
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Chemical Properties
Boiling point 785.7±60.0 °C(Predicted)
density 1.359±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO
form Powder
pka16.46±0.30(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Usage And Synthesis
UsesLY 393558 acts as a 5HT1B/D receptor antagonist which has been shown to limit serotonin reuptake on extracellular levels. Potential use in the treatment of IBS.
Biological ActivityDual 5-HT 1B/1D receptor antagonist (pK B values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC 50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine in vivo . Also acts as an antagonist at 5-HT 2A and 5-HT 2B receptors (pK i values are 7.29 and 7.35 respectively).
in vivo

LY393558 (1-20 mg/kg; p.o., single) raises extracellular levels of 5-HT to 200-250% at 1 mg/kg in guinea pigs model, while levels of 5-HT to approximately 1500% at the highest dose 20 mg/kg[1].
LY393558 (20 mg/kg; p.o., single) completely abolishes the reduction of levels of 5-HT induced by tetrodotoxin (1μM) in guinea pigs model[1].
LY393558 (1-20 mg/kg; p.o., single) significantly increases extracellular levels of 5-HT in rats model[1].
LY393558 (5 mg/kg/day; p.o., 21 days) can still elicit a further increase in extracellular 5-HT in chronic treatment[1].

Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
Dosage:1-20 mg/kg
Administration:p.o., single
Result:Extracellular levels of 5-HT reached 200-250% at 1 mg/kg, while levels of 5-HT reached approximately 1500% at the highest dose 20 mg/kg.
Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
Dosage:20 mg/kg
Administration:p.o., single
Result:Completely abolished the reduction of levels of 5-HT induced by tetrodotoxin (1μM).
Animal Model:Male Lister Hooded rats (290-320 g)[1]
Dosage:1-20 mg/kg
Administration:p.o., single
Result:Significantly increased extracellular levels of 5-HT.
Animal Model:Male Lister Hooded rats (290-320 g)[1]
Dosage:5 mg/kg/day
Administration:p.o., 21 days
Result:Still elicited a further increase in extracellular 5-HT in chronic treatment.
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Preparation Products And Raw materials
Tag:1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide(271780-64-4) Related Product Information
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide 6-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole ACT-132577 LU 208075-d3 PRX-08066 ACT 373898