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| | Unii-Q70OH404hr Basic information |
| Product Name: | Unii-Q70OH404hr | | Synonyms: | Implitapide [inn];Unii-Q70OH404hr;2(S)-Cyclopentyl-2-[4-(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-ylmethyl)phenyl]-N-[2-hydroxy-1(R)-phenylethyl]acetamide;(alphaS)-alpha-Cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-[(1R)-2-hydroxy-1-phenylethyl]benzeneacetamide;(2S)-2-cyclopentyl-2-[3-[(2,4-dimethylpyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide;AEGR 427;Benzeneacetamide, α-cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-[(1R)-2-hydroxy-1-phenylethyl]-, (αS)- | | CAS: | 177469-96-4 | | MF: | C35H37N3O2 | | MW: | 531.69 | | EINECS: | | | Product Categories: | | | Mol File: | 177469-96-4.mol |  |
| | Unii-Q70OH404hr Chemical Properties |
| Boiling point | 742.9±60.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 14.22±0.10(Predicted) | | color | White to off-white |
| | Unii-Q70OH404hr Usage And Synthesis |
| Uses | Implitapide, is a microsomal triglyceride transfer protein (MTP) inhibitor. | | in vivo | Implitapide (3.2 mg/kg/d) significantly reduces the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (p<0.01). Implitapide (3.2 mg/kg/d) markedly suppresses lipid-stained lesions in the mice fed the western-type diet (WD). Implitapide (3.2 mg/kg/d) significantly decreases lesion area by 83% compared with that of the WD group (p<0.01). ApoE KO mice fed a WD containing Implitapide (1, 5, and 15 mg/kg/d) for 14 weeks have been shown to reduce significantly both plaque area (by 66, 78, and 93%, respectively) and lipid moieties within plaque (4.3, 2.6, and 0%, respectively, versus 9.5% in controls). Implitapide at a dosage of approximately 3.2 mg/kg/d significantly reduces the lipid-stained aortic lesions by 83% in apoE KO mice[1]. |
| | Unii-Q70OH404hr Preparation Products And Raw materials |
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