(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺
| 中文名称 | (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺 |
|---|---|
| 中文同义词 | (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺;化合物SU1498;(E)-2-氰基-3-(4-羟基-3,5-二异丙基苯基)-N-(3-苯基丙基)丙烯酰胺;SU1498,VEGFR2抑制剂;化合物SU1498,10 MM DMSO 溶液;168835-82-3;SU1498;SU1498 (AG 1498) |
| 英文名称 | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide |
| 英文同义词 | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy;SU1498, >98%;Tyrphostin SU 1498, >98%;CS-1481;(E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE;CHEMBL261508 |
| CAS号 | 168835-82-3 |
| 分子式 | C25H30N2O2 |
| 分子量 | 390.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 168835-82-3.mol |
| 结构式 |  |
(E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺 性质
| 熔点 | 126 °C |
|---|---|
| 沸点 | 590.6±50.0 °C(Predicted) |
| 密度 | 1.100±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 溶于二甲基亚砜。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.30±0.36(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20° 下保存长达 3 个月。 |
| InChI | 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+ |
| InChIKey | JANPYFTYAGTSIN-FYJGNVAPSA-N |
| SMILES | N(CCCc2ccccc2)C(=O)\C(=C\c1cc(c(c(c1)C(C)C)O)C(C)C)\C#N |
| CAS 数据库 | 168835-82-3 |
| Target | Value |
|
KDR
() |
SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海关编码 | 2926.90.4801 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6535 | (E)-2-氰基-3-(4-羟基-3,5-二异丙苯基)-N-(3-苯基丙基)丙烯酰胺 SU1498 | 168835-82-3 | 5mg | 794.93元 |
| 2026/06/06 | U0103 | SU 1498 SU 1498 | 168835-82-3 | 5mg | 150元 |