L-Vinylglycine hydrochloride manufacturers
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| | L-Vinylglycine hydrochloride Basic information |
| Product Name: | L-Vinylglycine hydrochloride | | Synonyms: | L-Vinylglycine hydrochloride;(S)-vinylglycine hydrochloride;(2S)-2-aminobut-3-enoic acid hydrochloride;L-Vinylglycine HCl;(S)-2-Amino-3-butenoic Acid Hydrochloride;(S)-2-AMinobut-3-enoic acid hydrochloride | | CAS: | 75266-38-5 | | MF: | C4H8ClNO2 | | MW: | 137.56482 | | EINECS: | | | Product Categories: | | | Mol File: | 75266-38-5.mol |  |
| | L-Vinylglycine hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid | | Optical Rotation | Consistent with structure |
| | L-Vinylglycine hydrochloride Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (S)-2-aminobut-3-enoic acid hydrochloride from (S)-2-(benzyloxycarbonylamino)-3-butenoic acid methyl ester: (S)-2-(benzyloxycarbonylamino)-3-butenoic acid methyl ester (0.905 g, 3.61 mmol) was suspended in 6 M hydrochloric acid solution (20 mL). The reaction mixture was heated to reflux for 2 hours and subsequently cooled to room temperature. Extraction was partitioned with dichloromethane (DCM) and the aqueous phase was again washed with DCM. After combining the organic phases, the aqueous phase was concentrated under vacuum to give a white solid product. Purification by acetone recrystallization resulted in the white crystalline product (S)-2-aminobut-3-enoic acid hydrochloride in a yield of 0.350 g and 71% yield. The structure of the product was confirmed by 1H-NMR (500 MHz, DMSO-d6): δ 8.32 (2H, broad single peak, NH2), 6.02-6.11 (1H, multiple peaks, CH=CH2), 5.50-5.75 (2H, multiple peaks, CH=CH2), 4.68-4.73 (1H, multiple peaks, CHCO2H). | | References | [1] Tetrahedron, 1985, vol. 41, # 19, p. 4347 - 4358
[2] Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4817 - 4820
[3] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 9, p. 1927 - 1930
[4] Tetrahedron Letters, 1984, vol. 25, # 14, p. 1425 - 1428
[5] Patent: US9434762, 2016, B2. Location in patent: Page/Page column 92 |
| | L-Vinylglycine hydrochloride Preparation Products And Raw materials |
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