3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE manufacturers
|
| | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE Basic information |
| Product Name: | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE | | Synonyms: | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE;3-N-Boc-N-methyl amino aniline;(3-Aminophenyl)methylcarbamic acid tert-butyl ester;tert-butyl 3-aMinophenyl(Methyl)carbaMate;3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE (Related Reference);TERT-BUTYL N-(3-AMINOPHENYL)-N-METHYLCARBAMATE;Carbamic acid, N-(3-aminophenyl)-N-methyl-, 1,1-dimethylethyl ester;N1-Boc-N1-methylbenzene-1,3-diamine | | CAS: | 528882-16-8 | | MF: | C12H18N2O2 | | MW: | 222.28 | | EINECS: | | | Product Categories: | | | Mol File: | 528882-16-8.mol |  |
| | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | Off-white to light brown Solid |
| | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-(N-tert-butoxycarbonyl-N-methylamino)aniline from tert-butyl methyl(3-nitrophenyl)carbamate: the product of step b (3.30 g, 13.1 mmol), 10% palladium-carbon catalyst (300 mg), and a THF-MeOH solvent mixture (1:1, 50 mL) were added to a round-bottom flask. The system was evacuated and displaced three times with hydrogen. The reaction mixture was stirred vigorously overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give a white solid product (2.90 g, 99% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.10 (1H, t), 6.62 (2H, m), 6.50 (1H, m), 3.66 (2H, br s), 3.22 (3H, s), 1.46 (9H, s). | | References | [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2253 - 2261
[2] Patent: WO2004/101533, 2004, A1. Location in patent: Page 26
[3] Patent: WO2004/98609, 2004, A1. Location in patent: Page/Page column 24-25
[4] Patent: WO2016/20698, 2016, A1. Location in patent: Page/Page column 59; 64; 65
[5] Patent: US2011/237620, 2011, A1. Location in patent: Page/Page column 34-35 |
| | 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE Preparation Products And Raw materials |
|