H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

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H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 manufacturers
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Basic information
Product Name:H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Synonyms:THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2;PKA INHIBITOR (5-22) AMIDE;PKI (5-22), AMIDE;PKI-ALPHA (5-22) AMIDE (HUMAN, MOUSE, RABBIT, RAT);PROTEIN KINASE A INHIBITOR (5-22) AMIDE;WIPTIDE;TTYADFIASGRTGRRNAI-NH2;CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE
CAS:100853-58-5
MF:C84H137N29O26
MW:1969.17
EINECS:
Product Categories:peptide
Mol File:100853-58-5.mol
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Structure
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. -15°C
Safety Information
MSDS Information
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Usage And Synthesis
UsesPKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].
References[1] Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. DOI:10.1152/ajpregu.2001.280.4.R935
[2] Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80. DOI:10.1042/bj2640371
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Preparation Products And Raw materials
Tag:H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2(100853-58-5) Related Product Information
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH PROTEIN KINASE A INHIBITOR FRAGMENT 5-24 AMIDE TRIFLUOROACETATE SALT CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-24) AMIDE PKA Inhibitor Fragment (6-22) amide H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Asn-Tyr-Pro-Leu-Glu-Leu-Tyr-Glu-Arg-Val-Arg-Thr-Gly-Cys PROTEIN KINASE C (19-35) H-Val-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH H-Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val-OH H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn-OH