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| | PAZ 417 Basic information |
| Product Name: | PAZ 417 | | Synonyms: | PAZ 417;2-(1-(4-(tert-butyl)benzyl)-5-(m-tolyl)-1H-indol-3-yl)-2-oxoaceticacid;HSXLMAFNWCSZGP-UHFFFAOYSA-N;Plasminogen activator inhibitor-1,PAI-1,Serpin family,Abeta,inhibit,Inhibitor,Amyloid-β,Alzheimer's disease,BBB-penetrated,β-amyloid peptide,orally active,Aleplasinin,memory deficiency;1H-Indole-3-acetic acid, 1-[[4-(1,1-dimethylethyl)phenyl]methyl]-5-(3-methylphenyl)-α-oxo-;2-{1-[(4-tert-butylphenyl)methyl]-5-(3-methylphenyl)-1H-indol-3-yl}-2-oxoacetic acid;Aleplasinin, 10 mM in DMSO;(1-(4-(1,1-Dimethylethyl)benzyl)-5-(3-methylphenyl)-1H-indol-3-yl)oxoacetic acid | | CAS: | 481629-87-2 | | MF: | C28H27NO3 | | MW: | 425.51888 | | EINECS: | | | Product Categories: | | | Mol File: | 481629-87-2.mol |  |
| | PAZ 417 Chemical Properties |
| Melting point | 128-129 °C | | Boiling point | 616.9±47.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (587.52 mM; Need ultrasonic) | | pka | 2.13±0.54(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | PAZ 417 Usage And Synthesis |
| Uses | Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2]. | | References | [1] Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4. DOI:10.1038/cr.2008.89
[2] Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433. DOI:10.1016/j.tips.2021.03.006 |
| | PAZ 417 Preparation Products And Raw materials |
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